This article critically evaluates the Medicines and Healthcare products Regulatory Agency’s announcement, in March 2008, that GlaxoSmithKline would not face prosecution for deliberately withholding trial data, which revealed not only that Seroxat was ineffective at treating childhood depression but also that it increased the risk of suicidal behaviour in this patient group. The decision not to prosecute followed a four and a half year investigation and was taken on the grounds that the law at the relevant time was insufficiently clear. (...) This article assesses the existence of significant gaps in the duty of candour which had been assumed to exist between drugs companies and the regulator, and reflects upon what this episode tells us about the robustness, or otherwise, of the UK’s regulation of medicines. (shrink)

I know about you only from your valuable books and from the little that was communicated to me by telephone in Moscow in September. Nevertheless, we share a warm interest in Greek culture generally and philosophy in particular.

How physicians approach patients and the problems they present is much influenced by the conceptual models around which their knowledge is organized. In this paper the implications of the biopsychosocial model for the study and care of a patient with an acute myocardial infarction are presented and contrasted with approaches used by adherents of the more traditional biomedical model. CiteULike Connotea Del.icio.us What's this?

Criticism and recommendations are very much welcome. Please don't hesitate to contact me with them. -/- .

Agency is the human capacity to freely choose one’s thoughts, motivations and actions without undue internal or external influences; it is distinguished from decisional capacity. Four well-known conditions that can deeply affect agency are depression, demoralization, existential distress, and family dysfunction. The study reviews how they may diminish agency in persons whose circumstances may lead them to consider or request euthanasia or assisted suicide. Since agency has been a relatively neglected dimension of autonomous choice at the end of life, it (...) is argued that to respect the autonomy of individuals, it is essential to establish their agency. (shrink)

Ethical theory in business ethics texts lacks sufficient specificity to be used as a tool of analysis. The result is that business faculty do not see the course in business ethics as helpful to their students, and the students do not see the course as helpful in their careers.A further difficulty is the inclusion of material which is not seen by business faculty, as appropriate or germane to the practice of decision-making. Issues such as the legitimacy of the corporation, or (...) capitalism versus Marxism, are of Iittle interest or help to the person in business.Finally, the text cases are too often of a policy nature, and do not deal with issues faced by a majority of those in business. The result is the lack of engaging the moral imagination of the students.Unless the course is redesigned so that it is seen by business faculty as more relevant, it will continue to be required by only a small number of business programs. (shrink)

Wang Yangming (1472-1529) and his School of Mind dominated the intellectual world of sixteenth-century Ming China (1368-1644), and his Confucian philosophy has since remained an essential component of East Asian philosophical discourse. Yet, the volume of publications on him in the Western-language literature has consistently paled in comparison to the volume of scholarship on classical Chinese philosophy, modern Chinese philosophy, Buddhism, and Daoism. Studying Wang Yangming: History of a Sinological Field explains the history of writing in the West about the (...) famed Ming dynasty scholar-official. From eighteenth-century French Jesuit books to English-language publications in 2020, this book provides a historical overview and summary of a literature published by scholars attempting to grapple with one of the most influential Confucians in the history of China, East Asia, and the world. (shrink)

The revival of Confucianism in China since the Reform and Opening is a topic that has received much scholarly attention. Beginning in the 1980s, this revival has included the establishment of a multitude of research institutes and study societies; local, national, and international conferences and symposiums; the restoration of historical sites; the introduction of a Confucian curriculum into schools; and an increasingly voluminous scholarship.1 Reasons for the revival include government policy and the search for “a new source of ideological legitimacy (...) for the state”; “a renewed academic interest” among intellectuals searching “for ways of dealing with China’s current social and political predicament”; the... (shrink)

Prior research indicates that managers’ dark personality traits increase their tendency to engage in disruptive and unethical organizational behaviors including accounting earnings management. Other research suggests that the prevalence of dark personalities in management may represent an accidental byproduct of selecting managers with accompanying desirable attributes that fit the stereotype of a “strong leader.” Our paper posits that organizations may hire some managers who have dark personality traits because their willingness to push ethical boundaries aligns with organizational objectives, particularly in (...) the accounting context where ethical considerations are especially important. Using several validation studies and experiments, we find that experienced executives and recruiting professionals favor hiring a candidate with dark personality traits into an accounting management position over an otherwise better-qualified candidate when the hiring organization faces pressure to manage earnings. Our results help to illuminate why individuals with dark personality traits may effectively compete for high-level accounting positions. (shrink)

Draft Chapter for Chinese Philosophy and Its Thinkers: From Ancient Times to the Present Day .

Current psychological research on causal inference is dominated by two basic approaches: the covariation approach and the mechanism approach. This article reviews these two approaches, evaluates the contributions and limitations of each approach, and suggests how these approaches might be integrated into a more comprehensive framework. Covariation theorists assume that cognizers infer causal relations from conditional probabilities computed over samples of multiple events, but they do not provide an adequate account of how cognizers constrain their search for candidate causes and (...) relevant evidence. Mechanism theorists assume that cognizers use their knowledge of potential mechanisms to infer the causes of individual events, but they do not account for the origins of this kind of knowledge. Theorists might integrate these approaches into a framework that overcomes these limitations by (1) examining important relations between cognizers' beliefs about the nature of causality, the logic of causal inference, and the processes cognizers use to make causal inferences, and (2) providing a more complete account of cognizers' conceptions of causality and the origins of those conceptions. (shrink)

The course in business ethics is required by an increasing number of business programs. Accordingly, it seems appropriate to evaluate the text materials used from the perspective of the business student.Relative to early criticisms, recent texts represent considerable improvements in their use of case materials and in the manner by which they involve the student in decision-making situations. However, there are two distortions present in all of the texts examined. First, they concentrate too heavily on cases of a policy, or (...) general management, nature. The result is an inadequate coverage of the functional areas of the firm in which graduates begin their employment. Second, they concentrate too heavily on manufacturing firms, and thus do not introduce students to the ethical problems found where they are most likely to work, in service firms. (shrink)

The transhumanist project of reshaping human beings by promoting their improvement through technological innovations has a broad agenda. This study focuses on the enhancement of the human organism through genetic modification techniques. Transhumanism values and a discussion of their philosophical background provide a framework to understand its ideals. Genetics and ethics are employed to assess the claims of the transhumanist program of human enhancement. A succinct description of central concepts in genetics and an explanation of current techniques to edit the (...) human genome serve to assess the capabilities and limitations of editing techniques. Potential benefits and liabilities of human enhancement through genome editing are discussed to appraise its feasibility. Ethical considerations of genome editing inform a reflection on the implications of introducing heritable changes in the genome of individuals. It is concluded that the transhumanist program is underpinned by a large number of hypotheses rather than by sufficient evidence. (shrink)

Semën [Simon] Liudvigovich Frank was born in Moscow, the son of a doctor. He studied law at Moscow University, joined a student Marxist group headed by P.B. Struve, and as a result was barred by the Russian authorities from living in any of the Russian “university cities.” He continued his university education at the Universities of Berlin and Munich. His first published work was a critique of Marx’s theory of value. Between 1902 and 1905 he divided his time among Berlin, (...) Munich, and Moscow. In 1902 he published his first philosophical essay, on Nietzsche’s doctrine of Fernstenliebe. He was a contributor—along with Nicolas Berdyaev, S.N. Bulgakov, and Struve—to three influential symposium volumes: Problemy idealizma [Problems of idealism], Vekhi [Signposts], and Iz glubiny [De profundis]. This last work was printed but its release was blocked by Soviet censorship. All of these works were originally published in Moscow; all of them have, in the past three or four years, been republished in Moscow, but for more than seventy years they were banned in the Soviet Union and could be reprinted only abroad. (shrink)

For researchers and students interested in the connections between theoretically informed work and the possibilities for bettering people's everyday lives, this ...

After being recalled to Beijing in 1510 for evaluation and reassignment in the wake of his two-year exile to Guizhou and his period of service as a magistrate, Wang Yangming was assigned to a succession of posts at the capital that kept him there through 1512. During that short time, he remained disillusioned with the Ming court and high politics and chose to put his energies into fostering a philosophical movement. He believed that by restoring the “way of master-disciple relations (...) and friendship,” he could help propagate the learning of the sages. To that end, he held jiangxue gatherings with colleagues and friends and carried on an active correspondence. In those venues, Wang Yangming engaged others with his ideas about the goal of sagehood, the obstacles to attaining it, and the methods for overcoming those obstacles. The following article reconstructs this critical period in Wang Yangming's philosophical development and the intellectual movement he sought to foster, as well as the status of his philosophy as of this point in time. -/- . (shrink)

Ethical theory in business ethics texts lacks sufficient specificity to be used as a tool of analysis. The result is that business faculty do not see the course in business ethics as helpful to their students, and the students do not see the course as helpful in their careers.A further difficulty is the inclusion of material which is not seen by business faculty, as appropriate or germane to the practice of decision-making. Issues such as the legitimacy of the corporation, or (...) capitalism versus Marxism, are of Iittle interest or help to the person in business.Finally, the text cases are too often of a policy nature, and do not deal with issues faced by a majority of those in business. The result is the lack of engaging the moral imagination of the students.Unless the course is redesigned so that it is seen by business faculty as more relevant, it will continue to be required by only a small number of business programs. (shrink)

Nie Bao 聶豹 (1487-1563) was a Neo-Confucian philosopher and scholar-official of sixteenth-century Ming China. In his Ming ru xue an 明儒學案 (Case studies of Ming Confucians), Huang Zongxi 黃宗羲placed him in the Jiangxi (Jiangyou 江右) group of Wang Yangming followers. The goal of this article is to provide a sketch of Nie Bao’s political trajectory and intellectual development from his early years until he was imprisoned in 1547, as well as translation of important documents pertaining to that trajectory and development. (...) By the time of his imprisonment, Nie Bao had articulated the essential elements of his philosophy of realizing centeredness and returning to silence, and with that, his own unique interpretation of the meaning of the extension of the innate knowledge of the good. -/- 第二十一届明史國際學術研討會 論文匯編 Proceedings of the Twenty-First International Conference of the Chinese Ming History Society. (shrink)

In a review in JHS lxxxix 127 Dr M. L. West gives as an example of ‘a certain innocence on matters of literary history’ the belief that seven-stringed lyres ‘came in’ in the seventh century B.C. Since the emphasis in the context is upon rigorous down-dating, what Dr West seems to be saying is that seven-stringed lyres were not in use amongst the Greeks before about 600 B.C. I hope that I do not misunderstand Dr West's contention: the purpose of (...) this short note is to suggest, with the greatest respect and deference, that another view of the matter may perhaps be permissible.Let us ignore the seven-stringed musical instrument shown on the Ayia Triadha sarcophagus, because evidence from the Late Bronze Age may be thought too remote to be relevant to early Hellenic musical practice. Let us also leave aside ancient opinions associating Terpander with the seven-stringed lyre and assigning him to the first half of the seventh century B.C.. Dr West may well regard the putting of trust in such testimonies as evidence of incorrigible amateurism. There remains, nevertheless, a contemporary witness to the existence of seven-stringed lyres amongst the Greeks of the seventh century B.C.In JHS lxxi 248, fig. 8, there is illustrated a fragment of a Subgeometric dinos of the first half of the seventh century B.C. from the excavations at Old Smyrna. On the piece is painted a seven-stringed lyre. The lines representing strings are carefully distinguished and spaced. It would be extravagant to assert that the artist could not count, or that he was suffering from hallucinations, or that he was imagining a type of instrument never seen by himself or his customers. In short, a tentative suggestion may be made—with due deference and hesitation: scholars, including those whom in this particular matter Dr West would, it seems, classify as innocents, ‘can seriously argue’ that seven-stringed lyres were reintroduced to Greece or ‘came in’ well within the first half of the seventh century B.C. (shrink)

L.P.: Earlier, Georgii Liudvigovich, we spoke at some length about your personal acquaintance with such distinguished Russian émigré scholars and thinkers as Fr. Vasilii Zen'kovskii, N.O. Losskii, and Fr. Georgii Florovskii. Today I'd like to ask you about your meetings in Moscow with the late A.F. Losev.

Neisseria gonorrhoeae, the bacterium that causes the sexually transmitted disease gonorrhea, demonstrates extensive antigenic heterogeneity in its surface components. The organism has the capacity to switch on and off the synthesis of different versions of components such as pili, outer membrane proteins, and lipopolysaccharide. Recent studies have shown that the gonococcus uses novel and complex mechanisms, of types not described previously, to store different versions of genetic information for surface proteins, and to regulate expression of those genes.

Keywords: A theological approach to understanding time and change in a modern way must consider the relationships between thermal physics and time as elucidated during the past century and a half. The fact of temporal change, including death and decay, has been a religious problem since antiquity, so that some traditions have simply attempted to transcend the world of change. However, a major current of the Christian tradition has seen change as a fundamental aspect of God's creation, and one with (...) which God becomes identified in the Incarnation. This implies approval of history, as having an ultimate value, rather than transcendence of it.We examine thermodynamics, and especially its Second Law, in order to understand more precisely the issues of temporal change. The Second Law states a universal tendency toward increasing disorder, and several implications of this law are discussed. Of particular significance, however, is the work of Prigogine and others on nonequilibrium thermodynamics, drawing attention to such phenomena as the enhancement of chemical reaction rates and the formation of “dissipative structures” in nonequilibrium situations. Such possibilities may be of considerable importance for understanding chemical and biological evolution.These ideas can be included in an evolutionary picture in which, following Teilhard de Chardin, the Body of Christ is seen as the future of evolution‐an “ultimate dissipative structure” in which the world of time and change is united with God. Suffering, death, and decay receive their meaning from the future. Within this framework it is therefore possible to believe that the material world of history may be part of the eschatological future and that science provides hints, though not predictions, of how that may happen. (shrink)

Ian Barbour has distinguished eight theologies of God's role in nature, together with corresponding models of divine activity. This essay examines these ideas in the light of a theology of the cross. Three of Barbour's approaches—the neo‐Thomist, the kenotic, and the existentialist—are able to provide different aspects of a theology of divine action that is consistent with belief that God's definitive revelation takes place in the Crucifixion and Resurrection of Jesus of Nazareth. These approaches encourage attention to a part of (...) traditional doctrines of Providence, the idea that God acts by “cooperation” with natural processes. The kenotic character of divine involvement in the world means that the regularities of the basic interactions of physics are maintained. The idea of cooperation can be extrapolated into the past, to give some insight into ways of understanding God's activity in originating the universe. (shrink)

FOR MANY YEARS the received wisdom--proclaimed by certain physicists and philosophers of physics and received by certain metaphysicians--was that, in Bertrand Russell's inimitable phrase, "time is an unimportant and superficial characteristic of reality. Past and future must be acknowledged to be as real as the present." Moreover, according to Russell, "it is a mere accident that we have no memory of the future"--presumably because the future, regarded as no less determinate than the past, is held to be equally "there" to (...) be known and hence "remembered.". (shrink)

ABSTRACTStudents of Ming philosophy and the thought of Wang Yangming likely know that the 1960s–1970s was a period during which many scholarships in this field of study were produced in the English language. Indeed, it has been almost half a century since a group of scholars came together at the University of Hawaii to present papers on Wang Yangming in commemoration of the fifth centenary of his birth. That group included, for example, Wing-tsit Chan, David Nivison, and Du Weiming. These (...) scholars, along with two others not present—Julia Ching and Carsun Chang—played a transformative role in introducing Wang Yangming to an English-reading audience. But, the history behind their achievement, as well as how they interpreted him for that audience, has yet to be written. This paper provides a synopsis of that history, explaining why the scholars chose to write about him and what they said about his life and ideas. (shrink)

Wang Yangming 王陽明 (1472-1529) was one of China's most influential Ruist philosophers. The publication widely regarded as most representative of his Ruism is the three-volume Record of Instructions for Practice. Wang Yangming’s followers kept records of statements he made and conversations he held when discussing his Ruist learning with them. During and after his lifetime, these records were compiled in three volumes. The third volume was gathered together and edited by his ardent follower Qian Dehong 錢德洪, who then published it (...) in 1556. This book is a modern, bilingual Chinese-English edition of the third volume with annotations and commentary. (shrink)

Wang Yangming 王陽明 (1472-1529) was one of China's most influential Ruist philosophers. The publication widely regarded as most representative of his Ruism is the three-volume Record of Instructions for Practice. Wang Yangming’s followers kept records of statements he made and conversations he held when discussing his Ruist learning with them. During and after his lifetime, these records were compiled in three volumes. The third volume was gathered together and edited by his ardent follower Qian Dehong 錢德洪, who then published it (...) in 1556. This book is a modern, bilingual Chinese-English edition of the third volume with annotations and commentary. (shrink)